Michael R. Moore, Ph.D.
Professor
Department: Biochemistry
& Microbiology
Research Cluster: Cancer Biology
Marshall University School of Medicine
Education and Experience
Michael R. Moore, Ph.D.Professor
Department: Biochemistry
& Microbiology
Research Cluster: Cancer Biology
Marshall University School of Medicine
Ph.D., University of Georgia, 1975
Postdoctoral Research, University of Iowa, 1975 - 1978
Major Research Interests
HORMONE RESPONSIVENESS IN HUMAN BREAST CANCER - Molecular mechanisms of progestin inhibition of programmed cell death and stimulation of proliferation and invasiveness in human breast cancer cells.
Representative publications:
Moore, M. R., Zhou, J. L., Blankenship, K. A., Strobl J. S., Edwards D. P. and Gentry R.N. A sequence in the 5' flanking region confers progestin responsiveness on the human c-myc gene. J. Steroid Biochem. Mol. Biol. 62: 243-252, 1997.
Moore, M. R., Conover, J. L., Franks, K. M. Progestin effects on long-term growth, death, and bcl-xl in breast cancer cells. Biochem. Biophys. Res. Commun. 277: 650-654, 2000.
Moore, M.R. A rationale for inhibiting progesterone-related pathways to combat breast cancer. Current Cancer Drug Targets. 4: 183-189, 2004.
Moore, M.R., Spence, J.B., Kiningham, K.K., and Dillon, J.L. Progestin inhibition of cell death in human breast cancer cell lines. J. Steroid Biochem. Mol. Biol. 98: 218-227, 2006.
Holley, A.K., Kiningham, K.K., Spitz D.R., Edwards D.P., Jenkins J.T., Moore M.R. (2009) Progestin stimulation of manganese superoxide dismutase and invasive properties in T47D human breast cancer cells. J. Steroid Biochem. Mol. Biol. 117:23-30, 2009.