|
Awarded
the
ASPET-Astellas award for Translational Pharmacology the year 2009, from
the American Society of Pharmacology and Experimental Therapeutics. |
| Selected for
The Marshall University Distinguished Artists and Scientists Award (MU-DASA) for the year 2009 |
| Kathleen
C.
Brown, an undergraduate student in the Dasgupta lab was awarded the
Sigma-Xi Grants-in-Aid research grant from NASA, for the year 2009, for
her research proposal “Nicotinic Receptor Signaling in Retinal Angiogenesis.” |
|
Assistant Professor Physiology & Toxicology Joan C. Edwards School of Medicine Room 435-J 1700 Third Avenue Huntington, WV 25755 E-mail : dasgupta@marshall.edu |
|
Hello,
As you can see above, I am an assistant professor with the Department of Pharmacology, Physiology and Toxicology. Originally from India, I arrived at Marshall University after completing postdoctoral fellowships at the College of Physicians and Surgeons, Columbia University, NY and the H. Lee Moffitt Cancer Center, Tampa, Florida.
Studies in my laboratory examine how components of tobacco can promote the progression of lung cancer. Nicotine is the major active and addictive component of cigarette smoke. Our research focuses on how nicotine can facilitate the growth and progression of lung cancers. Although nicotine is not a carcinogen, my studies indicate that it can induce proliferation, angiogenesis and metastasis of lung cancers. Additionally, it can also protect lung cancer cells against chemotherapeutic drug-induced apoptosis. These actions of nicotine are mediated by high affinity nicotinic acetylcholine receptors on lung cancer cells. My lab tries to decipher the signaling pathways by which nicotine promotes the growth and survival of lung tumors. On a more basic level, we try to analyze the physiological function of these neuronal receptors in the lung. |
| Some of the questions we address are:
1) Role of nicotinic receptors in growth of human small cell lung cancer |
|
Another major project in my laboratory is focused Capsaicin is the major active ingredient of chilli peppers. Preliminary data in our laboratory shows that capsaicin manifests anti-cancer activity in human small cell lung cancer. We plan to extend these studies to animal models and examine the molecular pathways, which contribute to this process. The transient receptor potential V (TRPV) family of receptors mediates the biological activities of capsaicin. Our future studies will attempt to identify novel ligands for TRPV receptors and test their anti-cancer activity. |
Selected Publications:
A. Chapters In Scholarly Books 2. Dasgupta, P. and Chellappan, S. (2007) Chromatin immunoprecipitation assays: Molecular Analysis of chromatin modification and gene regulation, In: CANCER GENOMICs AND PROTEOMICS Ed. Paul Fischer, Methods Mol. Biol., 383, 135-152. Humana Press Inc., NJ, USA.
B. Journal Articles 1. Egleton, R. D., Brown, K.C. and Dasgupta, P. (2009) Angiogenic Activity of Nicotinic Acetylcholine Receptors: Implications in Tobacco-related Vascular Diseases. Pharmacology & Therapeutics 121, 2, 205-223. * equal second author
1. Pillai S, Dasgupta P., Chellappan SP (2009) Chromatin immunoprecipitation assays: analyzing transcription factor binding and histone modifications in vivo. In: CHROMATIN PROTOCOLS Ed. SP Chellappan, Methods Mol. Biol., 523, 323-329. Humana Press Inc., NJ, USA
2. Dasgupta, P., Rizwani, W., Pillai, S., Kinkade,R., Rastogi,S., Banerjee, S., Kovacs, M., , Carless, M., , E., Kim, Haura, E., Coppola, D. and Chellappan, S. (2009) Nicotine induces cell proliferation, invasion and epithelial-mesenchymal transition in a variety of human cancer cell lines. International J. Cancer 124, 1, 36-45 .
3. Egelton, R.D., Brown, K.C., Dasgupta, P. (2008) Nicotinic Acetylcholine Receptors: Multiple Roles in Proliferation and Inhibition of Apoptosis Trends Pharmacol Sci , 29, 151-158.
4. Kinkade, R., Dasgupta, P., Carie, A., Pernazza, D., Carless, M., Pillai, S., Lawrence, N., Sebti, S.M., Chellappan, S. (2008) A small molecule disruptor of Rb/Raf-1 interaction inhibits cell proliferation, angiogenesis, and growth of human tumor xenografts in nude mice. Cancer Res., 68, 3810-3818.
5. Dasgupta, P., Rastogi, S., Joshi, B., Pillai, S., Ordonez, D., Morris, M., Haura, E. and Chellappan, S. (2006) Nicotine induces cell proliferation by b-arrestin mediated activation of Src and Rb-Raf-1 pathway. J. Clin. Invest., 116, 2208-17.
6. Dasgupta, P., Kinkade, R., Joshi, B., DeCook, C., Haura, E. and Chellappan, S. (2006) Nicotine inhibits apoptosis induced by chemotherapeutic drugs by upregulating XIAP and survivin. Proc. Natl. Acad. Sci., USA, 103, 6332-7.
7. Rastogi, S., Joshi, B., Dasgupta, P*., Morris, M., Wright, K. and Chellappan, S. (2006) Prohibitin facilitates cellular senescence by recruiting specific co-repressors to inhibit E2F-target genes. Mol. Cell. Biol. 26, 4161-71.
8. Dasgupta, P., Padmanabhan, J. and Chellappan, S. (2006) Rb function in the apoptosis and senescence of non-neuronal and neuronal cells: Role in Oncogenesis. Curr. Mol. Medicine 6, 719-29.
9. Kinkade,R., Dasgupta, P. and Chellappan, S. (2006) The ABCs of Targeting Raf: Novel approaches to Cancer Therapy. Current Cancer Therapy Reviews 2, 305-14.
10. Dasgupta, P. and Chellappan, S. (2006). Nicotine-mediated cell proliferation and angiogenesis: New Twists to an Old Story. Cell Cycle 5, 2324-28